Version 5.4
Mus musculus Protein: Smg7
Summary
InnateDB Protein IDBP-198705.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Smg7
Protein Name Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000073144
InnateDB Gene IDBG-198701 (Smg7)
Protein Structure
UniProt Annotation
Function Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0051721 protein phosphatase 2A binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0008150 biological_process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0045111 intermediate filament cytoskeleton
Protein Structure and Domains
PDB ID MGI:2682334
InterPro IPR019458 Telomerase activating protein Est1
PFAM PF10374
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5RJH6
PhosphoSite PhosphoSite-Q5RJH6
TrEMBL Q3UKQ9
UniProt Splice Variant
Entrez Gene 226517
UniGene Mm.470782
RefSeq NP_001005507
MGI ID
MGI Symbol Smg7
OMIM
CCDS CCDS35740
HPRD
IMGT
EMBL AK129101 AK145908 BC082789 BC086651
GenPept AAH82789 AAH86651 BAC97911 BAE26742

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca