Version 5.4
Mus musculus Protein: Usp48
Summary
InnateDB Protein IDBP-198842.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Usp48
Protein Name ubiquitin specific peptidase 48
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000055016
InnateDB Gene IDBG-198840 (Usp48)
Protein Structure
UniProt Annotation
Function Recognizes and hydrolyzes the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly- ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID MGI:2158502
InterPro IPR000626 Ubiquitin-like
IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR006615 Peptidase C19, ubiquitin-specific peptidase, DUSP domain
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain
IPR029071 Ubiquitin-related domain
PFAM PF00240
PF14560
PF00443
PF06337
PRINTS
PIRSF
SMART SM00213
SM00695
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3V0C5
PhosphoSite PhosphoSite-Q3V0C5
TrEMBL
UniProt Splice Variant
Entrez Gene 170707
UniGene Mm.438731
RefSeq NP_570949
MGI ID
MGI Symbol Usp48
OMIM
CCDS CCDS38924
HPRD
IMGT
EMBL AK133251 AK166158 AK220190 BC021769
GenPept AAH21769 BAD90375 BAE21579 BAE38603

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca