Version 5.4
Mus musculus Protein: Gchfr
Summary
InnateDB Protein IDBP-198995.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gchfr
Protein Name GTP cyclohydrolase I feedback regulator
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000060835
InnateDB Gene IDBG-198993 (Gchfr)
Protein Structure
UniProt Annotation
Function Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Nucleus membrane {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004857 enzyme inhibitor activity
GO:0005515 protein binding
GO:0016597 amino acid binding
GO:0019899 enzyme binding
GO:0030742 GTP-dependent protein binding
GO:0044549 GTP cyclohydrolase binding
Biological Process
GO:0006461 protein complex assembly
GO:0009890 negative regulation of biosynthetic process
GO:0043105 negative regulation of GTP cyclohydrolase I activity
GO:0051291 protein heterooligomerization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030425 dendrite
GO:0031965 nuclear membrane
GO:0042470 melanosome
GO:0043234 protein complex
Protein Structure and Domains
PDB ID MGI:2443977
InterPro IPR009112 GTP cyclohydrolase I, feedback regulatory protein
PFAM PF06399
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P99025
PhosphoSite PhosphoSite-P99025
TrEMBL Q4VAF4
UniProt Splice Variant
Entrez Gene 320415
UniGene
RefSeq NP_796131
MGI ID
MGI Symbol Gchfr
OMIM
CCDS CCDS38204
HPRD
IMGT
EMBL AK028116 AK028122 BC096406 BC132450 BC132478 CH466519
GenPept AAH96406 AAI32451 AAI32479 BAC25756 BAC25761 EDL27938

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca