InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gchfr

Summary

InnateDB Gene

IDBG-198993.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gchfr

Gene Name

GTP cyclohydrolase I feedback regulator

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000046814

Encoded Proteins

IDBP-198995

GTP cyclohydrolase I feedback regulator

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137880:
GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:119167773-119172390

Strand

Forward strand

Band

Transcripts

ENSMUST00000057454

ENSMUSP00000060835

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0005515	protein binding
GO:0016597	amino acid binding
GO:0019899	enzyme binding
GO:0030742	GTP-dependent protein binding
GO:0044549	GTP cyclohydrolase binding

Biological Process

GO:0006461	protein complex assembly
GO:0009890	negative regulation of biosynthetic process
GO:0043105	negative regulation of GTP cyclohydrolase I activity
GO:0051291	protein heterooligomerization