InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rnf123

Summary

InnateDB Protein

IDBP-199022.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnf123

Protein Name

ring finger protein 123

Synonyms

BC003945; Kpc1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040803

InnateDB Gene

IDBG-199020 (Rnf123)

Protein Structure

UniProt Annotation

Function

Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Biological Process

GO:0008150	biological_process
GO:0016567	protein ubiquitination

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:2148796

InterPro

IPR001841 Zinc finger, RING-type
IPR001870 B30.2/SPRY domain
IPR003877 SPla/RYanodine receptor SPRY
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR018355 SPla/RYanodine receptor subgroup

PFAM

PF13639
PF14634
PF00622

PRINTS

PIRSF

SMART

SM00184
SM00449

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5XPI3