InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prcp

Summary

InnateDB Protein

IDBP-199229.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prcp

Protein Name

prolylcarboxypeptidase (angiotensinase C)

Synonyms

2510048K03Rik; 2610104A14Rik; AI451719; HUMPCP; PCP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000075429

InnateDB Gene

IDBG-199227 (Prcp)

Protein Structure

UniProt Annotation

Function

Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH (By similarity). {ECO:0000250}.

Subcellular Localization

Lysosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0004180	carboxypeptidase activity
GO:0005515	protein binding
GO:0008236	serine-type peptidase activity

Biological Process

GO:0002155	regulation of thyroid hormone mediated signaling pathway
GO:0002353	plasma kallikrein-kinin cascade
GO:0003085	negative regulation of systemic arterial blood pressure
GO:0006508	proteolysis
GO:0042593	glucose homeostasis
GO:0043535	regulation of blood vessel endothelial cell migration
GO:0060055	angiogenesis involved in wound healing
GO:0097009	energy homeostasis
GO:2000377	regulation of reactive oxygen species metabolic process