InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Prcp

Summary

InnateDB Gene

IDBG-199227.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prcp

Gene Name

prolylcarboxypeptidase (angiotensinase C)

Synonyms

2510048K03Rik; 2610104A14Rik; AI451719; HUMPCP; PCP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000061119

Encoded Proteins

IDBP-199229

prolylcarboxypeptidase (angiotensinase C)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137509:
The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:92875253-92934573

Strand

Forward strand

Band

Transcripts

ENSMUST00000076052

ENSMUSP00000075429

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0004180	carboxypeptidase activity
GO:0005515	protein binding
GO:0008236	serine-type peptidase activity

Biological Process

GO:0002155	regulation of thyroid hormone mediated signaling pathway
GO:0002353	plasma kallikrein-kinin cascade
GO:0003085	negative regulation of systemic arterial blood pressure
GO:0006508	proteolysis
GO:0042593	glucose homeostasis
GO:0043535	regulation of blood vessel endothelial cell migration
GO:0060055	angiogenesis involved in wound healing
GO:0097009	energy homeostasis
GO:2000377	regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005764	lysosome
GO:0045178	basal part of cell
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000137509

View Gene Order

ENSBTAG00000033731

Not yet available

Pathways

NETPATH

REACTOME

REACT_224553

Hemostasis pathway

REACT_239392

Intrinsic Pathway pathway

REACT_235097

Formation of Fibrin Clot (Clotting Cascade) pathway

KEGG

mmu04974

Protein digestion and absorption pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_326

Intrinsic Pathway pathway

REACT_2051

Formation of Fibrin Clot (Clotting Cascade) pathway

REACT_604

Hemostasis pathway

KEGG

hsa04974

Protein digestion and absorption pathway

INOH

PID NCI

Cross-References

SwissProt

Q7TMR0

TrEMBL

UniProt Splice Variant

Entrez Gene

72461

UniGene

Mm.389969 Mm.39856 Mm.478495

RefSeq

NM_028243

OMIM

CCDS

CCDS21452

HPRD

IMGT

MGI ID

MGI:1919711

MGI Symbol

Prcp

EMBL

AK011816 AK051677 AK054462 AK166282 BC026424 BC055022

GenPept

AAH26424 AAH55022 BAB27858 BAC34716 BAE20697 BAE38679

RNA Seq Atlas

72461