Version 5.4
Mus musculus Protein: Hpd
Summary
InnateDB Protein IDBP-199292.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hpd
Protein Name 4-hydroxyphenylpyruvic acid dioxygenase
Synonyms Fla; Flp; Hppd; Laf;
Species Mus musculus
Ensembl Protein ENSMUSP00000031398
InnateDB Gene IDBG-199290 (Hpd)
Protein Structure
UniProt Annotation
Function Key enzyme in the degradation of tyrosine. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Disease Associations Note=Defects in Hpd are the cause of tyrosinemia type III.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity
GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
GO:0046872 metal ion binding
Biological Process
GO:0006559 L-phenylalanine catabolic process
GO:0006572 tyrosine catabolic process
GO:0009072 aromatic amino acid family metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
Protein Structure and Domains
PDB ID MGI:96213
InterPro IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain
IPR005956 4-hydroxyphenylpyruvate dioxygenase
IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
PFAM PF00903
PRINTS
PIRSF PIRSF009283
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P49429
PhosphoSite PhosphoSite-P49429
TrEMBL D3Z1U3
UniProt Splice Variant
Entrez Gene 15445
UniGene
RefSeq NP_032303
MGI ID
MGI Symbol Hpd
OMIM
CCDS CCDS39265
HPRD
IMGT
EMBL AC163337 AK149416 BC013343 D29987 X59530
GenPept AAH13343 BAA06267 BAE28861 CAA42111

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca