InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hpd

Summary

InnateDB Gene

IDBG-199290.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hpd

Gene Name

4-hydroxyphenylpyruvic acid dioxygenase

Synonyms

Fla; Flp; Hppd; Laf

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029445

Encoded Proteins

IDBP-199292

4-hydroxyphenylpyruvic acid dioxygenase

IDBP-541469

4-hydroxyphenylpyruvic acid dioxygenase

IDBP-533729

4-hydroxyphenylpyruvic acid dioxygenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158104:
The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:123171807-123182725

Strand

Reverse strand

Band

Transcripts

ENSMUST00000031398	ENSMUSP00000031398
ENSMUST00000155092
ENSMUST00000144679	ENSMUSP00000118702
ENSMUST00000154713	ENSMUSP00000121922
ENSMUST00000156539
ENSMUST00000124110

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003868	4-hydroxyphenylpyruvate dioxygenase activity
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
GO:0046872	metal ion binding

Biological Process

GO:0006559	L-phenylalanine catabolic process
GO:0006572	tyrosine catabolic process
GO:0009072	aromatic amino acid family metabolic process
GO:0055114	oxidation-reduction process