InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DSC1

Summary

InnateDB Protein

IDBP-1993.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DSC1

Protein Name

desmocollin 1

Synonyms

CDHF1; DG2/DG3;

Species

Homo sapiens

Ensembl Protein

ENSP00000257197

InnateDB Gene

IDBG-1991 (DSC1)

Protein Structure

UniProt Annotation

Function

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.

Disease Associations

Tissue Specificity

Strongly expressed in epidermis, less in lymph node and tongue.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding

Biological Process

GO:0007156

homophilic cell adhesion

Cellular Component

GO:0005886	plasma membrane
GO:0005921	gap junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030057	desmosome
GO:0070062	extracellular vesicular exosome