InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rnasel

Summary

InnateDB Protein

IDBP-199300.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnasel

Protein Name

ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)

Synonyms

E230029I04Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000083385

InnateDB Gene

IDBG-199298 (Rnasel)

Protein Structure

UniProt Annotation

Function

Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress- response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11585831}. Mitochondrion {ECO:0000269PubMed:11585831}.

Disease Associations

Tissue Specificity

Expressed in spleen, thymus, lung, testis, kidney, liver and heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004519	endonuclease activity
GO:0004540	ribonuclease activity
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0019843	rRNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006364	rRNA processing
GO:0006397	mRNA processing
GO:0006468	protein phosphorylation
GO:0009103	lipopolysaccharide biosynthetic process
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051607	defense response to virus
GO:0090501	RNA phosphodiester bond hydrolysis

Cellular Component

GO:0005739	mitochondrion
GO:0016020	membrane
GO:0016363	nuclear matrix

Protein Structure and Domains

PDB ID

MGI:1098272

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002110 Ankyrin repeat
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR006567 PUG domain
IPR010440 Lipopolysaccharide kinase
IPR010513 KEN domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR020683 Ankyrin repeat-containing domain

PFAM