InnateDB Protein
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IDBP-19935.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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POLR3E
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Protein Name
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polymerase (RNA) III (DNA directed) polypeptide E (80kD)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000352140
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InnateDB Gene
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IDBG-19931 (POLR3E)
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Protein Structure
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Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
18
[view]
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Protein-Protein |
16
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
Accession |
GO Term |
GO:0001056
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RNA polymerase III activity
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GO:0003899
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DNA-directed RNA polymerase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006886
DNA-directed RNA polymerase III subunit Rpc5
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PFAM |
PF04801
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NVU0
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PhosphoSite |
PhosphoSite-Q9NVU0
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TrEMBL |
H3BSI5
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UniProt Splice Variant |
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Entrez Gene |
55718
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UniGene |
Hs.596127
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RefSeq |
NP_001244965
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HUGO |
HGNC:30347
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OMIM |
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CCDS |
CCDS58433
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HPRD |
15155
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IMGT |
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EMBL |
AB040885
AC009034
AC092338
AK001371
AK023160
AK023231
AK296813
AK300735
AY092085
BC000285
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GenPept |
AAH00285
AAM18215
BAA91655
BAA95976
BAB14437
BAB14481
BAG59386
BAG62408
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