Version 5.4
Homo sapiens Protein: BCL7B
Summary
InnateDB Protein IDBP-19938.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCL7B
Protein Name B-cell CLL/lymphoma 7B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000223368
InnateDB Gene IDBG-19936 (BCL7B)
Protein Structure
UniProt Annotation
Function May play a role in lung tumor development or progression.
Subcellular Localization
Disease Associations Note=BCL7B is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of BCL7B may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. {ECO:0000269PubMed:9860302, ECO:0000269PubMed:9931421}.
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:9860302, ECO:0000269PubMed:9931421}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID
InterPro IPR006804 BCL7
PFAM PF04714
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BQE9
PhosphoSite PhosphoSite-Q9BQE9
TrEMBL F2Z3H6
UniProt Splice Variant
Entrez Gene 9275
UniGene Hs.647051
RefSeq NP_001698
HUGO HGNC:1005
OMIM 605846
CCDS CCDS5550
HPRD 05786
IMGT
EMBL AC005089 AJ223979 AK123497 AK290091 BC000956 BC001967 BC009548 BX333744 CH471200 X89985
GenPept AAH00956 AAH01967 AAH09548 BAF82780 CAA11753 CAA62012 EAW69676 EAW69678

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca