InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Qpct

Summary

InnateDB Protein

IDBP-199420.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Qpct

Protein Name

glutaminyl-peptide cyclotransferase (glutaminyl cyclase)

Synonyms

5730422A13Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038732

InnateDB Gene

IDBG-199418 (Qpct)

Protein Structure

UniProt Annotation

Function

Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008233	peptidase activity
GO:0008270	zinc ion binding
GO:0016603	glutaminyl-peptide cyclotransferase activity

Biological Process

GO:0006508	proteolysis
GO:0017186	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase

Cellular Component

GO:0005576	extracellular region
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1917786

InterPro

IPR007484 Peptidase M28

PFAM

PF04389

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

MGI ID

MGI Symbol

OMIM

CCDS

HPRD

IMGT

EMBL

AK017598 AK037197 AK045974 BC020023

GenPept

AAH20023 BAB30831 BAC29748 BAC32556

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca