Version 5.4
Mus musculus Protein: Cacna1e
Summary
InnateDB Protein IDBP-199521.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cacna1e
Protein Name calcium channel, voltage-dependent, R type, alpha 1E subunit
Synonyms A430040I15; alpha1E; BII; Cach6; Cacnl1a6; Cav2.3; Cchra1;
Species Mus musculus
Ensembl Protein ENSMUSP00000004214
InnateDB Gene IDBG-199519 (Cacna1e)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005509 calcium ion binding
GO:0008331 high voltage-gated calcium channel activity
Biological Process
GO:0001662 behavioral fear response
GO:0002027 regulation of heart rate
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0007268 synaptic transmission
GO:0007626 locomotory behavior
GO:0008542 visual learning
GO:0019226 transmission of nerve impulse
GO:0019233 sensory perception of pain
GO:0030317 sperm motility
GO:0034765 regulation of ion transmembrane transport
GO:0042593 glucose homeostasis
GO:0042596 fear response
GO:0048265 response to pain
GO:0048266 behavioral response to pain
GO:0050877 neurological system process
GO:0055085 transmembrane transport
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
GO:0086010 membrane depolarization during action potential
GO:0090273 regulation of somatostatin secretion
Cellular Component
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:106217
InterPro IPR002048 EF-hand domain
IPR002077 Voltage-dependent calcium channel, alpha-1 subunit
IPR005449 Voltage-dependent calcium channel, R-type, alpha-1 subunit
IPR005821 Ion transport domain
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR014873 Voltage-dependent calcium channel, alpha-1 subunit, IQ domain
PFAM PF00036
PF13202
PF13405
PF00520
PF08016
PF08763
PRINTS PR00167
PR01633
PIRSF
SMART SM00054
SM01062
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E9QK20
UniProt Splice Variant
Entrez Gene 12290
UniGene Mm.409140
RefSeq
MGI ID
MGI Symbol Cacna1e
OMIM
CCDS
HPRD
IMGT
EMBL AC099707 AC101727 AC122040
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca