InnateDB Protein
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IDBP-199718.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Thrsp
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Protein Name
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thyroid hormone responsive SPOT14 homolog (Rattus)
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Synonyms
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S14;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000042988
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InnateDB Gene
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IDBG-199716 (Thrsp)
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Protein Structure
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Function |
Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA. May function as transcriptional coactivator. May modulate the transcription factor activity of THRB (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:20952656}. Cytoplasm {ECO:0000269PubMed:20952656}.
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Disease Associations |
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Tissue Specificity |
Mainly expressed in tissues that synthesize triglycerides. {ECO:0000269PubMed:15890771}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:109126
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InterPro |
IPR009786
Spot 14 family
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PFAM |
PF07084
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q62264
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PhosphoSite |
PhosphoSite-Q62264
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TrEMBL |
Q8BPB6
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UniProt Splice Variant |
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Entrez Gene |
21835
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UniGene |
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RefSeq |
NP_033407
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MGI ID |
3ONT
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MGI Symbol |
Thrsp
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OMIM |
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CCDS |
CCDS21458
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HPRD |
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IMGT |
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EMBL |
AK050300
AK077300
BC009165
CH466531
X95279
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GenPept |
AAH09165
BAC34175
BAC36737
CAA64600
EDL16296
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