InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ddost

Summary

InnateDB Protein

IDBP-199721.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ddost

Protein Name

dolichyl-di-phosphooligosaccharide-protein glycotransferase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030538

InnateDB Gene

IDBG-199719 (Ddost)

Protein Structure

UniProt Annotation

Function

Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004576	oligosaccharyl transferase activity
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity
GO:0005515	protein binding

Biological Process

GO:0006486	protein glycosylation
GO:0006487	protein N-linked glycosylation
GO:0018279	protein N-linked glycosylation via asparagine
GO:0034097	response to cytokine
GO:0042110	T cell activation

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0008250	oligosaccharyltransferase complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex