InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ddost

Summary

InnateDB Gene

IDBG-199719.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ddost

Gene Name

dolichyl-di-phosphooligosaccharide-protein glycotransferase

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028757

Encoded Proteins

IDBP-199721

dolichyl-di-phosphooligosaccharide-protein glycotransferase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000244038:
This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:138304730-138312628

Strand

Forward strand

Band

Transcripts

ENSMUST00000030538

ENSMUSP00000030538

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004576	oligosaccharyl transferase activity
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity
GO:0005515	protein binding

Biological Process

GO:0006486	protein glycosylation
GO:0006487	protein N-linked glycosylation
GO:0018279	protein N-linked glycosylation via asparagine
GO:0034097	response to cytokine
GO:0042110	T cell activation

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0008250	oligosaccharyltransferase complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex