Version 5.4
Mus musculus Protein: Srsf7
Summary
InnateDB Protein IDBP-199750.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Srsf7
Protein Name serine/arginine-rich splicing factor 7
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000070983
InnateDB Gene IDBG-199748 (Srsf7)
Protein Structure
UniProt Annotation
Function Required for pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA- binding is semi-sequence specific (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 10 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 74 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0048025 negative regulation of mRNA splicing, via spliceosome
GO:0051028 mRNA transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1926232
InterPro IPR000504 RNA recognition motif domain
IPR001878 Zinc finger, CCHC-type
PFAM PF00076
PF00098
PRINTS
PIRSF
SMART SM00360
SM00343
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BL97
PhosphoSite PhosphoSite-Q8BL97
TrEMBL Q3THA6
UniProt Splice Variant
Entrez Gene 225027
UniGene Mm.473035
RefSeq NP_666195
MGI ID
MGI Symbol Srsf7
OMIM
CCDS CCDS28988
HPRD
IMGT
EMBL AK032861 AK045884 AK082848 AK137795 AK168355 BC014857 BC025529 BC027391 CH466537
GenPept AAH14857 AAH25529 AAH27391 BAC28058 BAC32521 BAC38650 BAE23499 BAE40291 EDL38502

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca