Version 5.4
Mus musculus Gene: Srsf7
Summary
InnateDB Gene IDBG-199748.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Srsf7
Gene Name serine/arginine-rich splicing factor 7
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000024097
Encoded Proteins
IDBP-199750
serine/arginine-rich splicing factor 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Five transcript variants, four of them protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:80200089-80207305
Strand Reverse strand
Band E3
Transcripts
ENSMUST00000063417 ENSMUSP00000070983
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 10 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 74 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0048025 negative regulation of mRNA splicing, via spliceosome
GO:0051028 mRNA transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000115875
View Gene Order
ENSBTAG00000014891
Not yet available
Pathways
NETPATH
REACTOME
REACT_240247
mRNA 3'-end processing pathway
REACT_237682
Transport of Mature Transcript to Cytoplasm pathway
REACT_249110
mRNA Splicing pathway
REACT_235610
mRNA Splicing - Minor Pathway pathway
REACT_257346
RNA Polymerase II Transcription Termination pathway
REACT_253727
Cleavage of Growing Transcript in the Termination Region pathway
REACT_233572
Gene Expression pathway
REACT_260226
mRNA Splicing - Major Pathway pathway
REACT_232353
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
REACT_233950
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_242255
RNA Polymerase II Transcription pathway
KEGG
mmu03040
Spliceosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1849
mRNA 3'-end processing pathway
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_1753
mRNA Splicing - Minor Pathway pathway
REACT_1597
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_387
Cleavage of Growing Transcript in the Termination Region pathway
REACT_894
RNA Polymerase II Transcription Termination pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_1281
Transport of Mature Transcript to Cytoplasm pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
REACT_209718
RNA Polymerase II Transcription pathway
REACT_224643
Cleavage of Growing Transcript in the Termination Region pathway
REACT_205948
mRNA Splicing - Major Pathway pathway
REACT_206725
mRNA Splicing pathway
REACT_203211
mRNA 3'-end processing pathway
REACT_224602
Transport of Mature Transcript to Cytoplasm pathway
REACT_224606
RNA Polymerase II Transcription Termination pathway
REACT_226022
Gene Expression pathway
REACT_220982
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
REACT_226302
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_217207
mRNA Splicing - Minor Pathway pathway
KEGG
hsa03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt Q8BL97
TrEMBL Q3THA6
UniProt Splice Variant
Entrez Gene 225027
UniGene Mm.473035
RefSeq NM_001195485 NM_001195486 NM_001195487 NM_146083
OMIM
CCDS CCDS28988
HPRD
IMGT
MGI ID MGI:1926232
MGI Symbol Srsf7
EMBL AK032861 AK045884 AK082848 AK137795 AK168355 BC014857 BC025529 BC027391 CH466537
GenPept AAH14857 AAH25529 AAH27391 BAC28058 BAC32521 BAC38650 BAE23499 BAE40291 EDL38502
RNA Seq Atlas 225027

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca