Version 5.4
Mus musculus Protein: Kntc1
Summary
InnateDB Protein IDBP-200018.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kntc1
Protein Name kinetochore associated 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000031366
InnateDB Gene IDBG-200016 (Kntc1)
Protein Structure
UniProt Annotation
Function Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0007067 mitotic nuclear division
GO:0007093 mitotic cell cycle checkpoint
Cellular Component
GO:0000777 condensed chromosome kinetochore
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005828 kinetochore microtubule
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton
Protein Structure and Domains
PDB ID MGI:2673709
InterPro IPR017986 WD40-repeat-containing domain
IPR019527 RZZ complex, subunit KNTC1/ROD, C-terminal
PFAM PF10493
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8C3Y4
PhosphoSite PhosphoSite-Q8C3Y4
TrEMBL
UniProt Splice Variant
Entrez Gene 208628
UniGene Mm.441089
RefSeq NP_001035886
MGI ID
MGI Symbol Kntc1
OMIM
CCDS CCDS39274
HPRD
IMGT
EMBL AK084529 AK172905
GenPept BAC39211 BAD32183

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca