InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nexn

Summary

InnateDB Protein

IDBP-200034.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nexn

Protein Name

nexilin

Synonyms

1110046H09Rik; AA553326; NELIN;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037120

InnateDB Gene

IDBG-200032 (Nexn)

Protein Structure

UniProt Annotation

Function

Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250UniProtKB:Q0ZGT2, ECO:0000250UniProtKB:Q9Z2J4}. Cell junction, adherens junction {ECO:0000250UniProtKB:Q0ZGT2, ECO:0000250UniProtKB:Q9Z2J4}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Localizes to the cell-matrix AJ. Not found at the cell-cell AJ (By similarity). {ECO:0000250UniProtKB:Q0ZGT2, ECO:0000250UniProtKB:Q9Z2J4}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004683	calmodulin-dependent protein kinase activity
GO:0005515	protein binding
GO:0008307	structural constituent of muscle
GO:0051015	actin filament binding

Biological Process

GO:0006468	protein phosphorylation
GO:0030334	regulation of cell migration
GO:0048739	cardiac muscle fiber development
GO:0051493	regulation of cytoskeleton organization

Cellular Component

GO:0005856	cytoskeleton
GO:0005924	cell-substrate adherens junction
GO:0030018	Z disc

Protein Structure and Domains

PDB ID

MGI:1916060

InterPro

IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set

PFAM

PF07679

PRINTS

PIRSF

SMART

SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q7TPW1

PhosphoSite

PhosphoSite-Q7TPW1

TrEMBL

UniProt Splice Variant

Entrez Gene

68810

UniGene

RefSeq

NP_955759

MGI ID

MGI Symbol

Nexn

OMIM

CCDS

CCDS38673

HPRD

IMGT

EMBL

AC123075 AK135919 AK136097 AK136102 AK163414 BC052878

GenPept

AAH52878 BAE22724 BAE22818 BAE22822 BAE37339