Version 5.4
Mus musculus Gene: Nexn
Summary
InnateDB Gene IDBG-200032.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nexn
Gene Name nexilin
Synonyms 1110046H09Rik; AA553326; NELIN
Species Mus musculus
Ensembl Gene ENSMUSG00000039103
Encoded Proteins
IDBP-200034
nexilin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162614:
This gene encodes a filamentous actin-binding protein that may function in cell adhesion and migration. Mutations in this gene have been associated with dilated cardiomyopathy, also known as CMD1CC. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:152236986-152266320
Strand Reverse strand
Band H3
Transcripts
ENSMUST00000046045 ENSMUSP00000037120
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004683 calmodulin-dependent protein kinase activity
GO:0005515 protein binding
GO:0008307 structural constituent of muscle
GO:0051015 actin filament binding
Biological Process
GO:0006468 protein phosphorylation
GO:0030334 regulation of cell migration
GO:0048739 cardiac muscle fiber development
GO:0051493 regulation of cytoskeleton organization
Cellular Component
GO:0005856 cytoskeleton
GO:0005924 cell-substrate adherens junction
GO:0030018 Z disc
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000162614
View Gene Order
ENSBTAG00000008921
Not yet available
Cross-References
SwissProt Q7TPW1
TrEMBL
UniProt Splice Variant
Entrez Gene 68810
UniGene
RefSeq NM_199465 XM_006501990 XM_006501991 XM_006501992 XM_006501993 XM_006501997 XM_006501998 XM_006502000
OMIM
CCDS CCDS38673
HPRD
IMGT
MGI ID MGI:1916060
MGI Symbol Nexn
EMBL AC123075 AK135919 AK136097 AK136102 AK163414 BC052878
GenPept AAH52878 BAE22724 BAE22818 BAE22822 BAE37339
RNA Seq Atlas 68810

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca