InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Niacr1

Summary

InnateDB Protein

IDBP-200064.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Niacr1

Protein Name

niacin receptor 1

Synonyms

Gpr109a; Gpr109b; HM74; mHM74b; Niacr1; PUMA-G; Pumag;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000054104

InnateDB Gene

IDBG-200062 (Niacr1)

Protein Structure

UniProt Annotation

Function

Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. {ECO:0000269PubMed:15929991}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in lungs, spleen, heart, skeletal muscle and adipose tissue. {ECO:0000269PubMed:11745392, ECO:0000269PubMed:12646212}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001614	purinergic nucleotide receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005525	GTP binding
GO:0070553	nicotinic acid receptor activity

Biological Process

GO:0006915	apoptotic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0033031	positive regulation of neutrophil apoptotic process
GO:0035590	purinergic nucleotide receptor signaling pathway
GO:0050995	negative regulation of lipid catabolic process
GO:0070165	positive regulation of adiponectin secretion