InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Impdh2

Summary

InnateDB Protein

IDBP-200176.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Impdh2

Protein Name

inosine 5'-phosphate dehydrogenase 2

Synonyms

IMPD;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000079888

InnateDB Gene

IDBG-200174 (Impdh2)

Protein Structure

UniProt Annotation

Function

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. {ECO:0000255HAMAP- Rule:MF_03156}.

Subcellular Localization

Cytoplasm {ECO:0000255HAMAP-Rule:MF_03156}. Nucleus {ECO:0000255HAMAP-Rule:MF_03156}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003824	catalytic activity
GO:0003938	IMP dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0018580	nitronate monooxygenase activity
GO:0030554	adenyl nucleotide binding
GO:0046872	metal ion binding
GO:0047465	N-acylglucosamine-6-phosphate 2-epimerase activity

Biological Process

GO:0006051	N-acetylmannosamine metabolic process
GO:0006164	purine nucleotide biosynthetic process
GO:0006177	GMP biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0046651	lymphocyte proliferation
GO:0051289	protein homotetramerization
GO:0055114	oxidation-reduction process
GO:0060041	retina development in camera-type eye
GO:0071353	cellular response to interleukin-4

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005778	peroxisomal membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:109367

InterPro

IPR000262 FMN-dependent dehydrogenase
IPR000644 CBS domain
IPR001093 IMP dehydrogenase/GMP reductase
IPR004136 2-nitropropane dioxygenase, NPD
IPR005990 Inosine-5\'-monophosphate dehydrogenase
IPR007260 Putative N-acetylmannosamine-6-phosphate epimerase

PFAM

PF01070
PF00571
PF00478
PF03060
PF04131

PRINTS

PIRSF

PIRSF000130

SMART

SM00116

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt