InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wdr6

Summary

InnateDB Protein

IDBP-200297.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wdr6

Protein Name

WD repeat domain 6

Synonyms

mWDR6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070927

InnateDB Gene

IDBG-200295 (Wdr6)

Protein Structure

UniProt Annotation

Function

Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Note=Colocalizes in the cytoplasm with STK11/LKB1. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0043560	insulin receptor substrate binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0010507	negative regulation of autophagy

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0008180	COP9 signalosome
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

MGI:1930140

InterPro

IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain

PFAM

PF00400

PRINTS

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99ME2

PhosphoSite

PhosphoSite-Q99ME2

TrEMBL

Q8CFV1

UniProt Splice Variant

Entrez Gene

83669

UniGene

Mm.481124

RefSeq

NP_113569

MGI ID

MGI Symbol

Wdr6

OMIM

CCDS

CCDS23532

HPRD

IMGT

EMBL

AF348591 AK037181 AK146617 AK163752 BC035951 BC050894 BC054367 CH466560

GenPept

AAH35951 AAH50894 AAH54367 AAK31166 BAC29740 BAE27306 BAE37480 EDL21306