InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Abl2

Summary

InnateDB Protein

IDBP-200392.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abl2

Protein Name

v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)

Synonyms

AA536808; Abll; Arg;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027888

InnateDB Gene

IDBG-200390 (Abl2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030145	manganese ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007015	actin filament organization
GO:0010976	positive regulation of neuron projection development
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0051017	actin filament bundle assembly
GO:0051353	positive regulation of oxidoreductase activity
GO:0071300	cellular response to retinoic acid

Cellular Component

GO:0015629	actin cytoskeleton
GO:0016023	cytoplasmic membrane-bounded vesicle

Protein Structure and Domains

PDB ID

MGI:87860

InterPro

IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003646 SH3-like domain, bacterial-type
IPR011009 Protein kinase-like domain
IPR011511 Variant SH3 domain
IPR015015 F-actin binding
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM