InnateDB Protein
|
IDBP-20040.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
YY1
|
Protein Name
|
YY1 transcription factor
|
Synonyms
|
DELTA; INO80S; NF-E1; UCRBP; YIN-YANG-1;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000262238
|
InnateDB Gene
|
IDBG-20038 (YY1)
|
Protein Structure
|
|
Function |
Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'- GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). {ECO:0000269PubMed:15329343}.Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements.
|
Subcellular Localization |
Nucleus matrix {ECO:0000269PubMed:18026119, ECO:0000269PubMed:23385818, ECO:0000269PubMed:9493912}. Note=Associated with the nuclear matrix.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 202 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
|
Predicted by orthology |
Total |
16 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0000400
|
four-way junction DNA binding
|
GO:0001078
|
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
|
GO:0003677
|
DNA binding
|
GO:0003700
|
sequence-specific DNA binding transcription factor activity
|
GO:0003713
|
transcription coactivator activity
|
GO:0003714
|
transcription corepressor activity
|
GO:0003723
|
RNA binding
|
GO:0005515
|
protein binding
|
GO:0008270
|
zinc ion binding
|
GO:0044212
|
transcription regulatory region DNA binding
|
GO:0046872
|
metal ion binding
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR007087
Zinc finger, C2H2
IPR015880
Zinc finger, C2H2-like
IPR017114
Transcription factor yin/yang
|
PFAM |
PF00096
|
PRINTS |
|
PIRSF |
PIRSF037113
|
SMART |
SM00355
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P25490
|
PhosphoSite |
PhosphoSite-P25490
|
TrEMBL |
G3V3M8
|
UniProt Splice Variant |
|
Entrez Gene |
7528
|
UniGene |
Hs.740171
|
RefSeq |
NP_003394
|
HUGO |
HGNC:12856
|
OMIM |
600013
|
CCDS |
CCDS9957
|
HPRD |
02482
|
IMGT |
|
EMBL |
AL157871
BC037308
BC065366
M76541
M77698
Z14077
|
GenPept |
AAA59467
AAA59926
AAH37308
AAH65366
CAA78455
|
|
|