InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ip6k2

Summary

InnateDB Protein

IDBP-200503.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ip6k2

Protein Name

inositol hexaphosphate kinase 2

Synonyms

1500005N04Rik; AW050208; Ihpk2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000082091

InnateDB Gene

IDBG-200497 (Ip6k2)

Protein Structure

UniProt Annotation

Function

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Was first identified because of its ability to stimulate Na(+)-dependent phosphate cotransport (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in brain and lung, and at slightly lower levels in liver, kidney and testis. {ECO:0000269PubMed:10574768}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000832	inositol hexakisphosphate 5-kinase activity
GO:0005524	ATP binding
GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity
GO:0052723	inositol hexakisphosphate 1-kinase activity
GO:0052724	inositol hexakisphosphate 3-kinase activity

Biological Process

GO:0006817	phosphate ion transport
GO:0030308	negative regulation of cell growth
GO:0043065	positive regulation of apoptotic process
GO:0046854	phosphatidylinositol phosphorylation