InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ip6k2

Summary

InnateDB Gene

IDBG-200497.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ip6k2

Gene Name

inositol hexaphosphate kinase 2

Synonyms

1500005N04Rik; AW050208; Ihpk2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032599

Encoded Proteins

IDBP-200503

inositol hexaphosphate kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000068745:
This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:108795994-108806333

Strand

Forward strand

Band

Transcripts

ENSMUST00000085018

ENSMUSP00000082091

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000832	inositol hexakisphosphate 5-kinase activity
GO:0005524	ATP binding
GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity
GO:0052723	inositol hexakisphosphate 1-kinase activity
GO:0052724	inositol hexakisphosphate 3-kinase activity

Biological Process

GO:0006817	phosphate ion transport
GO:0030308	negative regulation of cell growth
GO:0043065	positive regulation of apoptotic process
GO:0046854	phosphatidylinositol phosphorylation