InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Celsr3

Summary

InnateDB Protein

IDBP-200593.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Celsr3

Protein Name

cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)

Synonyms

flamingo; Fmi1; mKIAA0812;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024238

InnateDB Gene

IDBG-200591 (Celsr3)

Protein Structure

UniProt Annotation

Function

Receptor that may have an important role in cell/cell signaling during nervous system formation.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in the CNS and in the eye. {ECO:0000269PubMed:10790539}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0001764	neuron migration
GO:0007156	homophilic cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007413	axonal fasciculation
GO:0032880	regulation of protein localization
GO:0042384	cilium assembly

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1858236

InterPro

IPR000203 GPS motif
IPR000742 Epidermal growth factor-like domain
IPR000832 GPCR, family 2, secretin-like
IPR001791 Laminin G domain
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR001881 EGF-like calcium-binding domain
IPR002049 EGF-like, laminin
IPR002126 Cadherin
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR015919 Cadherin-like
IPR017981 GPCR, family 2-like
IPR022624 Domain of unknown function DUF3497

PFAM