InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Celsr3

Summary

InnateDB Gene

IDBG-200591.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Celsr3

Gene Name

cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)

Synonyms

flamingo; Fmi1; mKIAA0812

Species

Mus musculus

Ensembl Gene

ENSMUSG00000023473

Encoded Proteins

IDBP-200593

cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000008300:
The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]
This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:108826320-108852963

Strand

Forward strand

Band

Transcripts

ENSMUST00000024238

ENSMUSP00000024238

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0001764	neuron migration
GO:0007156	homophilic cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007413	axonal fasciculation
GO:0032880	regulation of protein localization
GO:0042384	cilium assembly

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000008300

View Gene Order

ENSBTAG00000021846

Not yet available

Cross-References

SwissProt

Q91ZI0

TrEMBL

UniProt Splice Variant

Entrez Gene

107934

UniGene

Mm.39945

RefSeq

NM_080437 XM_006511621 XM_006511622 XM_006511623 XM_006511624 XM_006511625 XM_006511626

OMIM

CCDS

CCDS23539

HPRD

IMGT

MGI ID

MGI:1858236

MGI Symbol

Celsr3

EMBL

AC168054 AF188752 AF427498

GenPept

AAG17057 AAL25099

RNA Seq Atlas

107934