Version 5.4
Mus musculus Protein: Doc2b
Summary
InnateDB Protein IDBP-200611.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Doc2b
Protein Name double C2, beta
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000021209
InnateDB Gene IDBG-200609 (Doc2b)
Protein Structure
UniProt Annotation
Function Calcium sensor which positively regulates SNARE- dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes. {ECO:0000269PubMed:19033398, ECO:0000269PubMed:19410553, ECO:0000269PubMed:20150444, ECO:0000269PubMed:8902635}.
Subcellular Localization Cytoplasm. Cytoplasmic granule. Cell membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane in a calcium-dependent manner.
Disease Associations
Tissue Specificity Widely expressed. Expressed in pancreatic islet cells (at protein level). {ECO:0000269PubMed:17548353, ECO:0000269PubMed:8902635}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005544 calcium-dependent phospholipid binding
GO:0019905 syntaxin binding
Biological Process
GO:0008104 protein localization
GO:0031340 positive regulation of vesicle fusion
GO:0032024 positive regulation of insulin secretion
GO:0045956 positive regulation of calcium ion-dependent exocytosis
GO:0048791 calcium ion-dependent exocytosis of neurotransmitter
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0008021 synaptic vesicle
GO:0015630 microtubule cytoskeleton
GO:0031201 SNARE complex
Protein Structure and Domains
PDB ID MGI:1100497
InterPro IPR000008 C2 domain
IPR001565 Synaptotagmin
IPR014638 Double C2 protein, alpha/beta/gamma type
PFAM PF00168
PRINTS PR00360
PR00399
PIRSF PIRSF036931
SMART SM00239
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P70169
PhosphoSite PhosphoSite-P70169
TrEMBL Q924P1
UniProt Splice Variant
Entrez Gene 13447
UniGene Mm.5137
RefSeq NP_031899
MGI ID
MGI Symbol Doc2b
OMIM
CCDS CCDS25057
HPRD
IMGT
EMBL AF164955 AL669897 BC067030 CH466596 D85037
GenPept AAH67030 AAK73775 BAA12714 CAI26032 EDL12842

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca