InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Acadm

Summary

InnateDB Protein

IDBP-200679.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acadm

Protein Name

acyl-Coenzyme A dehydrogenase, medium chain

Synonyms

AU018656; MCAD;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000072483

InnateDB Gene

IDBG-200677 (Acadm)

Protein Structure

UniProt Annotation

Function

This enzyme is specific for acyl chain lengths of 4 to 16.

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003995	acyl-CoA dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0042802	identical protein binding
GO:0050660	flavin adenine dinucleotide binding
GO:0070991	medium-chain-acyl-CoA dehydrogenase activity

Biological Process

GO:0001889	liver development
GO:0005978	glycogen biosynthetic process
GO:0006082	organic acid metabolic process
GO:0006111	regulation of gluconeogenesis
GO:0006635	fatty acid beta-oxidation
GO:0007507	heart development
GO:0008152	metabolic process
GO:0009409	response to cold
GO:0009437	carnitine metabolic process
GO:0009791	post-embryonic development
GO:0019254	carnitine metabolic process, CoA-linked
GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0042594	response to starvation
GO:0045329	carnitine biosynthetic process
GO:0051791	medium-chain fatty acid metabolic process
GO:0051793	medium-chain fatty acid catabolic process
GO:0055007	cardiac muscle cell differentiation
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0030424	axon

Protein Structure and Domains

PDB ID

MGI:87867

InterPro

IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain
IPR013107 Acyl-CoA dehydrogenase, type 2, C-terminal
IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal

PFAM

PF02770
PF00441
PF08028
PF02771

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P45952

PhosphoSite