Version 5.4
Mus musculus Gene: Acadm
Summary
InnateDB Gene IDBG-200677.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Acadm
Gene Name acyl-Coenzyme A dehydrogenase, medium chain
Synonyms AU018656; MCAD
Species Mus musculus
Ensembl Gene ENSMUSG00000062908
Encoded Proteins
IDBP-200679
acyl-Coenzyme A dehydrogenase, medium chain
IDBP-533016
acyl-Coenzyme A dehydrogenase, medium chain
IDBP-538967
acyl-Coenzyme A dehydrogenase, medium chain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C6- and C12-acylCoA. In mice, deficiency of this gene can cause neonatal mortality as well as fasting and cold intolerance. This gene has multiple, intronless pseudogenes. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:153922357-153944632
Strand Reverse strand
Band H3
Transcripts
ENSMUST00000072697 ENSMUSP00000072483
ENSMUST00000156310 ENSMUSP00000122989
ENSMUST00000150070 ENSMUSP00000121714
ENSMUST00000137161
ENSMUST00000130713
ENSMUST00000135724
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003995 acyl-CoA dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0042802 identical protein binding
GO:0050660 flavin adenine dinucleotide binding
GO:0070991 medium-chain-acyl-CoA dehydrogenase activity
Biological Process
GO:0001889 liver development
GO:0005978 glycogen biosynthetic process
GO:0006082 organic acid metabolic process
GO:0006111 regulation of gluconeogenesis
GO:0006635 fatty acid beta-oxidation
GO:0007507 heart development
GO:0008152 metabolic process
GO:0009409 response to cold
GO:0009437 carnitine metabolic process
GO:0009791 post-embryonic development
GO:0019254 carnitine metabolic process, CoA-linked
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0042594 response to starvation
GO:0045329 carnitine biosynthetic process
GO:0051791 medium-chain fatty acid metabolic process
GO:0051793 medium-chain fatty acid catabolic process
GO:0055007 cardiac muscle cell differentiation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0030424 axon
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000117054
View Gene Order
ENSBTAG00000024240
Not yet available
Pathways
NETPATH
REACTOME
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_233858
Mitochondrial Fatty Acid Beta-Oxidation pathway
REACT_188937
Metabolism pathway
REACT_236353
Beta oxidation of octanoyl-CoA to hexanoyl-CoA pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_255591
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids pathway
REACT_261839
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA pathway
REACT_257219
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_257646
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
REACT_198602
PPARA activates gene expression pathway
KEGG
mmu00410
beta-Alanine metabolism pathway
mmu00280
Valine, leucine and isoleucine degradation pathway
mmu03320
PPAR signaling pathway pathway
mmu00640
Propanoate metabolism pathway
mmu00071
Fatty acid degradation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_1697
Beta oxidation of octanoyl-CoA to hexanoyl-CoA pathway
REACT_1708
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA pathway
REACT_160
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_1473
Mitochondrial Fatty Acid Beta-Oxidation pathway
REACT_1541
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
REACT_111217
Metabolism pathway
REACT_207951
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_215287
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids pathway
REACT_208669
Mitochondrial Fatty Acid Beta-Oxidation pathway
REACT_211406
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_219139
Metabolism pathway
REACT_207237
PPARA activates gene expression pathway
REACT_226458
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_220229
Beta oxidation of octanoyl-CoA to hexanoyl-CoA pathway
REACT_202075
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
KEGG
hsa00280
Valine, leucine and isoleucine degradation pathway
hsa00640
Propanoate metabolism pathway
hsa00071
Fatty acid degradation pathway
hsa03320
PPAR signaling pathway pathway
hsa00410
beta-Alanine metabolism pathway
INOH
INOH website
Propanoate metabolism pathway
INOH website
Valine Leucine Isoleucine degradation pathway
PID NCI
hnf3bpathway
FOXA2 and FOXA3 transcription factor networks
Cross-References
SwissProt
TrEMBL D6RFD7
UniProt Splice Variant
Entrez Gene 11364
UniGene Mm.10530 Mm.363481 Mm.404254
RefSeq NM_007382
OMIM
CCDS CCDS17924
HPRD
IMGT
MGI ID MGI:87867
MGI Symbol Acadm
EMBL AC087184
GenPept
RNA Seq Atlas 11364

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca