Version 5.4
Mus musculus Protein: Vps53
Summary
InnateDB Protein IDBP-200699.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vps53
Protein Name vacuolar protein sorting 53 (yeast)
Synonyms 2010002A08Rik; 2310040I21Rik; 3100002B05Rik; Hccs1;
Species Mus musculus
Ensembl Protein ENSMUSP00000061317
InnateDB Gene IDBG-200697 (Vps53)
Protein Structure
UniProt Annotation
Function May be involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0015031 protein transport
Cellular Component
GO:0000938 GARP complex
GO:0010008 endosome membrane
Protein Structure and Domains
PDB ID MGI:1915549
InterPro IPR007234 Vps53-like, N-terminal
IPR019515 Vacuolar protein sorting-associated protein 54
PFAM PF04100
PF10475
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CCB4
PhosphoSite PhosphoSite-Q8CCB4
TrEMBL
UniProt Splice Variant
Entrez Gene 68299
UniGene Mm.46397
RefSeq NP_080940
MGI ID
MGI Symbol Vps53
OMIM
CCDS CCDS25060
HPRD
IMGT
EMBL AK009970 AK019408 AK033495 AK049259 AL591129 BC034371
GenPept AAH34371 BAB26620 BAB31707 BAC28318 BAC33641 CAI35098

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca