Version 5.4
Mus musculus Protein: Col7a1
Summary
InnateDB Protein IDBP-200779.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Col7a1
Protein Name collagen, type VII, alpha 1
Synonyms AW209154;
Species Mus musculus
Ensembl Protein ENSMUSP00000026740
InnateDB Gene IDBG-200777 (Col7a1)
Protein Structure
UniProt Annotation
Function Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen. {ECO:0000250UniProtKB:Q02388, ECO:0000269PubMed:10523500}.
Subcellular Localization Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0007155 cell adhesion
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005576 extracellular region
GO:0005581 collagen trimer
GO:0005604 basement membrane
Protein Structure and Domains
PDB ID MGI:88462
InterPro IPR002035 von Willebrand factor, type A
IPR002223 Proteinase inhibitor I2, Kunitz metazoa
IPR003961 Fibronectin, type III
IPR008160 Collagen triple helix repeat
PFAM PF00092
PF00014
PF00041
PF01108
PF01391
PRINTS PR00759
PIRSF
SMART SM00327
SM00131
SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q63870
PhosphoSite PhosphoSite-Q63870
TrEMBL
UniProt Splice Variant
Entrez Gene 12836
UniGene Mm.6200
RefSeq NP_031764
MGI ID
MGI Symbol Col7a1
OMIM
CCDS CCDS40770
HPRD
IMGT
EMBL AC174646 S63654 U32107
GenPept AAB27492 AAB66593

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca