Version 5.4
Mus musculus Gene: Col7a1
Summary
InnateDB Gene IDBG-200777.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Col7a1
Gene Name collagen, type VII, alpha 1
Synonyms AW209154
Species Mus musculus
Ensembl Gene ENSMUSG00000025650
Encoded Proteins
IDBP-200779
collagen, type VII, alpha 1
IDBP-256748
collagen, type VII, alpha 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114270:
This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:108953586-108984875
Strand Forward strand
Band F2
Transcripts
ENSMUST00000026740 ENSMUSP00000026740
ENSMUST00000112070 ENSMUSP00000107701
ENSMUST00000127905
ENSMUST00000126780
ENSMUST00000149142
ENSMUST00000138588
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0007155 cell adhesion
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005576 extracellular region
GO:0005581 collagen trimer
GO:0005604 basement membrane
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000114270
View Gene Order
ENSBTAG00000019081
Not yet available
Pathways
NETPATH
REACTOME
REACT_199045
Collagen formation pathway
REACT_199046
Assembly of collagen fibrils and other multimeric structures pathway
REACT_198984
Collagen biosynthesis and modifying enzymes pathway
REACT_196595
Anchoring fibril formation pathway
REACT_206066
Extracellular matrix organization pathway
REACT_202342
Laminin interactions pathway
REACT_216309
Integrin cell surface interactions pathway
REACT_199052
Degradation of the extracellular matrix pathway
REACT_199055
Collagen degradation pathway
KEGG
mmu04974
Protein digestion and absorption pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13552
Integrin cell surface interactions pathway
REACT_150268
Anchoring fibril formation pathway
REACT_150180
Assembly of collagen fibrils and other multimeric structures pathway
REACT_121139
Collagen biosynthesis and modifying enzymes pathway
REACT_150401
Collagen degradation pathway
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_169262
Laminin interactions pathway
REACT_120729
Collagen formation pathway
KEGG
hsa04974
Protein digestion and absorption pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
integrin1_pathway
Beta1 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.6200
RefSeq NM_007738 XM_006511935 XM_006511937 XM_006511938 XM_006511939
OMIM
CCDS CCDS40770
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca