InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kcnk1

Summary

InnateDB Protein

IDBP-200796.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcnk1

Protein Name

potassium channel, subfamily K, member 1

Synonyms

AI788889; TWIK-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046103

InnateDB Gene

IDBG-200794 (Kcnk1)

Protein Structure

UniProt Annotation

Function

Weak inwardly rectifying potassium channel.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Widely expressed. Highest expression in brain, kidney, thyroid, salivary gland, adrenal gland, prostate, epididymis, uterus, placenta, colon and jejunum. Moderate expression in eyes, pituitary, pancreas, smooth muscle, testis and ovary. Very low levels in lung, aorta, liver, heart, skeletal muscle, thymus and spleen. In the brain, highest expression in cerebellar granule cells, brainstem, hippocampus and cerebral cortex.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005244	voltage-gated ion channel activity
GO:0005267	potassium channel activity

Biological Process

GO:0006813	potassium ion transport
GO:0034765	regulation of ion transmembrane transport
GO:0035094	response to nicotine
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0031526	brush border membrane

Protein Structure and Domains

PDB ID

MGI:109322

InterPro

IPR001779 Two pore domain potassium channel, TWIK-1
IPR003092 Two pore domain potassium channel, TASK family
IPR003280 Two pore domain potassium channel
IPR005408 Two pore domain potassium channel, TWIK family
IPR013099 Two pore domain potassium channel domain

PFAM

PF07885

PRINTS

PR01096
PR01095
PR01333
PR01586

PIRSF

PIRSF038061

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt