InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eif2b1

Summary

InnateDB Protein

IDBP-200816.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eif2b1

Protein Name

eukaryotic translation initiation factor 2B, subunit 1 (alpha)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031334

InnateDB Gene

IDBG-200814 (Eif2b1)

Protein Structure

UniProt Annotation

Function

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003743	translation initiation factor activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019003	GDP binding
GO:0030234	enzyme regulator activity

Biological Process

GO:0006412	translation
GO:0006413	translational initiation
GO:0006417	regulation of translation
GO:0006446	regulation of translational initiation
GO:0009408	response to heat
GO:0009749	response to glucose
GO:0014003	oligodendrocyte development
GO:0032057	negative regulation of translational initiation in response to stress
GO:0043087	regulation of GTPase activity
GO:0043434	response to peptide hormone
GO:0043547	positive regulation of GTPase activity
GO:0044237	cellular metabolic process
GO:0050790	regulation of catalytic activity
GO:0051716	cellular response to stimulus