InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Eif2b1

Summary

InnateDB Gene

IDBG-200814.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eif2b1

Gene Name

eukaryotic translation initiation factor 2B, subunit 1 (alpha)

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029388

Encoded Proteins

IDBP-200816

eukaryotic translation initiation factor 2B, subunit 1 (alpha)

IDBP-536798

eukaryotic translation initiation factor 2B, subunit 1 (alpha)

IDBP-538621

eukaryotic translation initiation factor 2B, subunit 1 (alpha)

IDBP-535845

eukaryotic translation initiation factor 2B, subunit 1 (alpha)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111361:
This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:124570213-124579131

Strand

Reverse strand

Band

Transcripts

ENSMUST00000031334	ENSMUSP00000031334
ENSMUST00000152716
ENSMUST00000135361	ENSMUSP00000122923
ENSMUST00000128920	ENSMUSP00000118760
ENSMUST00000135163	ENSMUSP00000120745

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003743	translation initiation factor activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019003	GDP binding
GO:0030234	enzyme regulator activity

Biological Process

GO:0006412	translation
GO:0006413	translational initiation
GO:0006417	regulation of translation
GO:0006446	regulation of translational initiation
GO:0009408	response to heat
GO:0009749	response to glucose
GO:0014003	oligodendrocyte development
GO:0032057	negative regulation of translational initiation in response to stress
GO:0043087	regulation of GTPase activity
GO:0043434	response to peptide hormone
GO:0043547	positive regulation of GTPase activity
GO:0044237	cellular metabolic process
GO:0050790	regulation of catalytic activity
GO:0051716	cellular response to stimulus