InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nxn

Summary

InnateDB Protein

IDBP-200852.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nxn

Protein Name

nucleoredoxin

Synonyms

l11Jus13;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021204

InnateDB Gene

IDBG-200850 (Nxn)

Protein Structure

UniProt Annotation

Function

Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A). {ECO:0000269PubMed:10903915, ECO:0000269PubMed:16604061, ECO:0000269PubMed:16764867, ECO:0000269PubMed:20970343}.

Subcellular Localization

Cytoplasm, cytosol. Nucleus.

Disease Associations

Tissue Specificity

Widely expressed with higher expression in testis and skin. {ECO:0000269PubMed:9119370}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004791	thioredoxin-disulfide reductase activity
GO:0005515	protein binding
GO:0016209	antioxidant activity
GO:0016491	oxidoreductase activity
GO:0047134	protein-disulfide reductase activity

Biological Process

GO:0016055	Wnt signaling pathway
GO:0030154	cell differentiation
GO:0030178	negative regulation of Wnt signaling pathway
GO:0031397	negative regulation of protein ubiquitination
GO:0055114	oxidation-reduction process
GO:0072358	cardiovascular system development