Version 5.4
Mus musculus Gene: Nxn
Summary
InnateDB Gene IDBG-200850.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nxn
Gene Name nucleoredoxin
Synonyms l11Jus13
Species Mus musculus
Ensembl Gene ENSMUSG00000020844
Encoded Proteins
IDBP-200852
nucleoredoxin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20400501
[Homo sapiens] NXN subfamily of proteins form a link between MYD88 and FLII (flightless I) to mediate negative regulation of the TLR4/MYD88 pathway.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167693:
Gene Information
Type Protein coding
Genomic Location Chromosome 11:76257198-76399140
Strand Reverse strand
Band B5
Transcripts
ENSMUST00000021204 ENSMUSP00000021204
ENSMUST00000131472
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004791 thioredoxin-disulfide reductase activity
GO:0005515 protein binding
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
GO:0047134 protein-disulfide reductase activity
Biological Process
GO:0016055 Wnt signaling pathway
GO:0030154 cell differentiation
GO:0030178 negative regulation of Wnt signaling pathway
GO:0031397 negative regulation of protein ubiquitination
GO:0055114 oxidation-reduction process
GO:0072358 cardiovascular system development
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000167693
View Gene Order
ENSBTAG00000000855
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.27915
RefSeq NM_008750
OMIM
CCDS CCDS25064
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca