InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cacybp

Summary

InnateDB Protein

IDBP-201113.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cacybp

Protein Name

calcyclin binding protein

Synonyms

SIP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000014370

InnateDB Gene

IDBG-201111 (Cacybp)

Protein Structure

UniProt Annotation

Function

May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11927578}. Cytoplasm {ECO:0000269PubMed:11927578}. Note=Cytoplasmic in unstimulated cultured neurons. Upon increase of calcium, it localizes to a ring around the nucleus. In neuroblastoma cells, after a Retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear and perinuclear fractions may be phosphorylated.

Disease Associations

Tissue Specificity

Highly expressed in brain and EAT cells. Expressed at low level in heart, muscle, and at very low level in the liver, spleen, lung, kidney and stomach. {ECO:0000269PubMed:9572262}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0007507	heart development
GO:0007568	aging
GO:0045740	positive regulation of DNA replication
GO:0055007	cardiac muscle cell differentiation
GO:0060416	response to growth hormone
GO:0060548	negative regulation of cell death
GO:0071277	cellular response to calcium ion

Cellular Component

GO:0005634	nucleus
GO:0005641	nuclear envelope lumen
GO:0005737	cytoplasm
GO:0030877	beta-catenin destruction complex
GO:0043005	neuron projection
GO:0044297	cell body
GO:0070062	extracellular vesicular exosome