Version 5.4
Mus musculus Protein: Blmh
Summary
InnateDB Protein IDBP-201259.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Blmh
Protein Name bleomycin hydrolase
Synonyms AI035728; Bh; Bmh;
Species Mus musculus
Ensembl Protein ENSMUSP00000021197
InnateDB Gene IDBG-201257 (Blmh)
Protein Structure
UniProt Annotation
Function The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0009636 response to toxic substance
GO:0042493 response to drug
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1345186
InterPro IPR004134 Peptidase C1B, bleomycin hydrolase
PFAM PF03051
PRINTS
PIRSF PIRSF005700
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R016
PhosphoSite PhosphoSite-Q8R016
TrEMBL E9QA53
UniProt Splice Variant
Entrez Gene 104184
UniGene Mm.454545
RefSeq NP_848760
MGI ID
MGI Symbol Blmh
OMIM
CCDS CCDS25073
HPRD
IMGT
EMBL AK035228 AK040799 AK051441 AK053872 AK150438 AK167325 AL603842 BC024090 BC027037 BC027362 BC027403
GenPept AAH24090 AAH27037 AAH27362 AAH27403 BAC28989 BAC30706 BAC34639 BAC35568 BAE29560 BAE39427 CAI35070

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca