Version 5.4
Mus musculus Gene: Blmh
Summary
InnateDB Gene IDBG-201257.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Blmh
Gene Name bleomycin hydrolase
Synonyms AI035728; Bh; Bmh
Species Mus musculus
Ensembl Gene ENSMUSG00000020840
Encoded Proteins
IDBP-201259
bleomycin hydrolase
IDBP-621769
bleomycin hydrolase
IDBP-621782
bleomycin hydrolase
IDBP-621786
bleomycin hydrolase
IDBP-539081
bleomycin hydrolase
IDBP-621784
bleomycin hydrolase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The encoded protein is a cytoplasmic cysteine peptidase involved in inactivation of bleomycin, a glycopeptide which is a component of combination chemotherapy regimens for cancer. This encoded enzyme is highly conserved, and it contains the signature active site residues of cysteine protease papain superfamily enzymes. It is postulated that this enzyme has protective effects against bleomycin-induced pulmonary fibrosis and bleomycin tumor resistance. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:76924809-76987379
Strand Forward strand
Band B5
Transcripts
ENSMUST00000021197 ENSMUSP00000021197
ENSMUST00000140193
ENSMUST00000155867
ENSMUST00000140781 ENSMUSP00000132608
ENSMUST00000125145 ENSMUSP00000132739
ENSMUST00000155053 ENSMUSP00000128505
ENSMUST00000146197 ENSMUSP00000118243
ENSMUST00000145732
ENSMUST00000168124 ENSMUSP00000130370
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0009636 response to toxic substance
GO:0042493 response to drug
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000108578
View Gene Order
ENSBTAG00000021370
Not yet available
Pathways
NETPATH
REACTOME
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_230745
Immune System pathway
REACT_199115
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_229531
Adaptive Immune System pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9PYU0
UniProt Splice Variant
Entrez Gene 104184
UniGene Mm.399785 Mm.431612 Mm.454545
RefSeq NM_178645
OMIM
CCDS CCDS25073
HPRD
IMGT
MGI ID MGI:1345186
MGI Symbol Blmh
EMBL AL603842
GenPept
RNA Seq Atlas 104184

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca