InnateDB Protein
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IDBP-201283.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Scarb1
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Protein Name
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scavenger receptor class B, member 1
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Synonyms
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AI120173; CD36; Cd36l1; Cla-1; Cla1; D5Ertd460e; Hdlq1; Hlb398; mSR-BI; SR-B1; SR-BI; Srb1; SRBI;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000083242
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InnateDB Gene
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IDBG-201281 (Scarb1)
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Protein Structure
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Function |
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (By similarity). Plays an important role in the uptake of HDL cholesteryl ester (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Membrane, caveola {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed primarily in liver and non-placental steroidogenic tissues.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:893578
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InterPro |
IPR002159
CD36 antigen
IPR005428
Adhesion molecule CD36
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PFAM |
PF01130
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PRINTS |
PR01609
PR01610
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q61009
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PhosphoSite |
PhosphoSite-Q61009
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TrEMBL |
Q4FK30
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UniProt Splice Variant |
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Entrez Gene |
20778
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UniGene |
Mm.474018
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RefSeq |
NP_058021
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MGI ID |
3R69
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MGI Symbol |
Scarb1
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OMIM |
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CCDS |
CCDS19683
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HPRD |
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IMGT |
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EMBL |
AK010622
AK028191
AK033114
AK154933
AK169906
BC004656
CH466529
CT010222
U37799
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GenPept |
AAC52378
AAH04656
BAB27068
BAC25802
BAC28157
BAE32934
BAE41449
CAJ18430
EDL19563
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