Homo sapiens Protein: HS3ST2
Summary
InnateDB Protein IDBP-20140.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HS3ST2
Protein Name heparan sulfate (glucosamine) 3-O-sulfotransferase 2
Synonyms 30ST2; 3OST2;
Species Homo sapiens
Ensembl Protein ENSP00000261374
InnateDB Gene IDBG-20138 (HS3ST2)
Protein Structure
UniProt Annotation
Function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N- unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.
Subcellular Localization Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in the brain and weakly expressed in the heart, placenta, lung and skeletal muscle. {ECO:0000269PubMed:9988767}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008146 sulfotransferase activity
GO:0033871 [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006024 glycosaminoglycan biosynthetic process
GO:0007623 circadian rhythm
GO:0008152 metabolic process
GO:0030203 glycosaminoglycan metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000863 Sulfotransferase domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00685
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y278
PhosphoSite PhosphoSite-
TrEMBL H3BMR2
UniProt Splice Variant
Entrez Gene 9956
UniGene Hs.733610
RefSeq NP_006034
HUGO HGNC:5195
OMIM 604056
CCDS CCDS10606
HPRD 04957
IMGT
EMBL AC130450 AC130466 AF105374 AF105375 AY359095 BC093734 BC093736
GenPept AAD30206 AAD30207 AAH93734 AAH93736 AAQ89453