InnateDB Protein
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IDBP-20140.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HS3ST2
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Protein Name
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heparan sulfate (glucosamine) 3-O-sulfotransferase 2
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Synonyms
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30ST2; 3OST2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000261374
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InnateDB Gene
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IDBG-20138 (HS3ST2)
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Protein Structure
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Function |
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N- unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in the brain and weakly expressed in the heart, placenta, lung and skeletal muscle. {ECO:0000269PubMed:9988767}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
0
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0008146
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sulfotransferase activity
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GO:0033871
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[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000863
Sulfotransferase domain
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00685
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y278
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PhosphoSite |
PhosphoSite-
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TrEMBL |
H3BMR2
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UniProt Splice Variant |
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Entrez Gene |
9956
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UniGene |
Hs.733610
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RefSeq |
NP_006034
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HUGO |
HGNC:5195
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OMIM |
604056
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CCDS |
CCDS10606
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HPRD |
04957
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IMGT |
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EMBL |
AC130450
AC130466
AF105374
AF105375
AY359095
BC093734
BC093736
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GenPept |
AAD30206
AAD30207
AAH93734
AAH93736
AAQ89453
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