InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ucp3

Summary

InnateDB Protein

IDBP-201428.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ucp3

Protein Name

uncoupling protein 3 (mitochondrial, proton carrier)

Synonyms

AI645527; Slc25a9; UCP-3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032958

InnateDB Gene

IDBG-201426 (Ucp3)

Protein Structure

UniProt Annotation

Function

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017077	oxidative phosphorylation uncoupler activity

Biological Process

GO:0000303	response to superoxide
GO:0001666	response to hypoxia
GO:0006631	fatty acid metabolic process
GO:0006839	mitochondrial transport
GO:0007568	aging
GO:0007584	response to nutrient
GO:0009409	response to cold
GO:0014823	response to activity
GO:0015992	proton transport
GO:0032868	response to insulin
GO:0032870	cellular response to hormone stimulus
GO:0048545	response to steroid hormone
GO:0051384	response to glucocorticoid