InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ucp3

Summary

InnateDB Gene

IDBG-201426.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ucp3

Gene Name

uncoupling protein 3 (mitochondrial, proton carrier)

Synonyms

AI645527; Slc25a9; UCP-3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032942

Encoded Proteins

IDBP-201428

uncoupling protein 3 (mitochondrial, proton carrier)

IDBP-267476

uncoupling protein 3 (mitochondrial, proton carrier)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175564:
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008]
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene\'s protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:100472990-100486432

Strand

Forward strand

Band

Transcripts

ENSMUST00000032958	ENSMUSP00000032958
ENSMUST00000107059	ENSMUSP00000102674
ENSMUST00000128044
ENSMUST00000133850

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017077	oxidative phosphorylation uncoupler activity

Biological Process

GO:0000303	response to superoxide
GO:0001666	response to hypoxia
GO:0006631	fatty acid metabolic process
GO:0006839	mitochondrial transport
GO:0007568	aging
GO:0007584	response to nutrient
GO:0009409	response to cold
GO:0014823	response to activity
GO:0015992	proton transport
GO:0032868	response to insulin
GO:0032870	cellular response to hormone stimulus
GO:0048545	response to steroid hormone
GO:0051384	response to glucocorticoid